The potential antiangiogenic effects of oridonin, a diterpenoid extracted from medicinal herbs

Oridonin, a compound commonly derived from medicinal plants, has been found to have anti-tumor effects in previous studies. A study found in the journal BMC Complementary and Alternative Medicine investigates the compound’s antiangiogenic effects.

  • The ability of oridonin to inhibit the growth of capillary networks in tumors in previous studies prompted the researchers to believe that antiangiogenic effects may at play.
  • They studied the ability of oridonin to inhibit the proliferation, apoptosis, migration, invasion, and tube formation of human umbilical vascular endothelial cells (HUVECs). An in vivo test using a zebrafish model was also conducted.
  • The researchers found oridonin to have the ability to inhibit the growth and development of HUVECs, and induce apoptosis. It also inhibited angiogenesis during the embryonic development of zebrafish and during tail fin regeneration tests.
  • Further analysis uncovered the ability to reduce the levels of VEGFA, VEGFR2, and VEGFR3 expressions in zebrafish while increasing the expression of the tumor-suppressing TP53 gene. In vivo tests showed strong effects against tumor growth and proliferation.

The researchers concluded that oridonin’s antiangiogenic properties allow it to effectively suppress tumor growth and metastasis.

Read the full text of the study at this link.

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Journal Reference:

Tian L, Xie K, Sheng D, Wan X, Zhu G. ANTIANGIOGENIC EFFECTS OF ORIDONIN. BMC Complementary and Alternative Medicine. 4 April 2017;17(192). DOI: 10.1186/s12906-017-1706-3

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