09/14/2018 / By Ellaine Castillo
Research reveals that citral can be used to induce apoptosis on drug-resistant cancer cells in a spheroid model. This study, which was published in BMC Complementary and Alternative Medicine, looked into the potential of citral to specifically target its cytotoxic activity against drug-resistant breast cancer cells.
There have been many advancements in breast cancer therapies throughout the years. Unfortunately, tumor recurrence and metastasis can lead to the formation of drug-resistant cancer cells. Previous studies have shown that citral exhibits cytotoxic activity against different cancer cell lines. However, no studies have been done to test its activity against drug-resistant breast cancer cells.
Results of these experiments show that citral can inhibit the growth and self-renewal of MDA-MB-231 spheroids by downregulating the Wnt/beta-catenin pathway. Aside from this, they also observed that citral’s ability to induce apoptosis follows a dose-dependent manner.
Read the full text of this study at this link.
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Journal reference
Nigjeh SE, Yeap SK, Nordin N, Kamalideghan B, Ky H, Rosli R. CITRAL INDUCED APOPTOSIS IN MDA-MB-231 SPHEROID CELLS. BMC Complementary and Alternative Medicine. 13 February 2018; 18(56). DOI: 10.1186/s12906-018-2115-y
Tagged Under: aroma, breast cancer, cancer, cancer treatment, cell death, citral, drug resistance, natural cures, Natural Treatments